Vitamins are the Antioxidant, which slows down the process called oxidative stress.
The origin of Diabetic Complication is linked with the phenomenon called as oxidative Stress. This process gives rise to the several free oxygen radicals in the body, which leads to alteration of several important biochemical pathways.
If we want to understand this oxidative stress process in Diabetic patients, we can see several studies have been carried out throughout the world. One of such piece of work published recently as a review article.
Diabetic patients with uncontrolled hyperglycemia are at risk for oxidative stress and complications, and oxidative stress may increase their requirement for vitamins with antioxidant effects.
Damaged tissues may have altered responses to vitamins and differing needs. Vitamins are important in the regulation of distinct metabolic pathways. Dual functions as an antioxidant and regulator of growth and differentiation would be of obvious importance in the repair and regeneration of cells that have died from oxidative damage. In general, the evidence does not support the use of supplements, and supplements are not recommended unless patients are deficient. Hyperglycemia with overproduction of superoxide radical is a first and common step in diverse pathways leading to dysregulation. Vitamin C (ascorbic acid) losses in urine may be excessive in diabetic patients and may require repletion to 200 mg in nonsmokers and 250 mg in smokers.
Hyperglycemia causes oxidative stress, which increases glycosylation and oxidation of proteins involved in the pathogenesis of the complications of diabetes. The role of certain vitamins is unique to the type of diabetic complication. See the list below.
Diabetic patients with uncontrolled hyperglycemia are at risk for oxidative stress and complications, and oxidative stress may increase their requirement for vitamins with antioxidant effects.
Damaged tissues may have altered responses to vitamins and differing needs. Vitamins are important in the regulation of distinct metabolic pathways. Dual functions as an antioxidant and regulator of growth and differentiation would be of obvious importance in the repair and regeneration of cells that have died from oxidative damage. In general, the evidence does not support the use of supplements, and supplements are not recommended unless patients are deficient. Hyperglycemia with overproduction of superoxide radical is a first and common step in diverse pathways leading to dysregulation. Vitamin C (ascorbic acid) losses in urine may be excessive in diabetic patients and may require repletion to 200 mg in nonsmokers and 250 mg in smokers.
Hyperglycemia causes oxidative stress, which increases glycosylation and oxidation of proteins involved in the pathogenesis of the complications of diabetes. The role of certain vitamins is unique to the type of diabetic complication. See the list below.
Epidemiologic observational studies suggested that low levels of vitamins A, E, and C may be associated with an increased oxidative stress and CAD
Adequate amounts of vitamins A, C, D, and E are required for normal insulin secretion.
Vitamins A, D, and E may alter vascular endothelial cell function.
Free radical production is increased in the elderly.
Chronic renal failure is associated with high plasma levels of retinoids and diminished 1-25 dihydroxy vitamin D3 levels.
Treatment with proper amounts of vitamins and antioxidants is best accomplished with a balanced diet including 3 servings of vegetables and 2 servings of fruits.
