Pediatric pulmonary arterial hypertension: Towards optimal classification, treatment strategies and outcome

W.M.H. Zijlstra

Pulmonary arterial hypertension (PAH) is a rare, intrinsic and progressive disease of the small pulmonary arteries and has a poor prognosis. In recent years, the development of PAH-targeted drugs and the introduction of evidence-based treatment guidelines have greatly improved quality of life and survival in adult PAH patients. Due to important differences between adult and pediatric PAH, adult data cannot be simply extrapolated to children. Unfortunately, data in pediatric PAH remain scarce. In this thesis, we evaluated classification, treatment strategies and (predictors of) survival in pediatric PAH. Furthermore, we assessed the value of a potential clinical endpoint for pediatric randomized controlled trials.

https://graphik-buro.nl/epub/willemijnzijlstra/