This work aims to provide concepts and ideas to induce a discussion and build a critical thinking on how important is to connect the work of universities with local fragile communities, in other words, to better understand the social role of the universities. In this regard, a general overview of social responsibility and territorial fragility concepts are presented. Then, university social networks and organizations together with case analyses illustrate the importance of projects developed within communities, in particular involving educational practices, to achieve urban regeneration and mutual learning between universities and society.