Oseltamivir, sold under the brand name Tamiflu, is an antiviral medication used to treat and prevent influenza A and influenza B, the viruses that cause the flu. Many medical organizations recommend it in people who have complications or are at high risk of complications within 48 hours of first symptoms of infection. Recommendations regarding oseltamivir are controversial as are criticisms of the recommendations. A 2014 Cochrane Review concluded that oseltamivir does not reduce hospitalizations, and that there is no evidence of reduction in complications of influenza. Oseltamivir was approved for medical use in the US in 1999. It is on the World Health Organization's List of Essential Medicines but was downgraded to "complementary" status in 2017.
Oseltamivir is a neuraminidase inhibitor, a competitive inhibitor of influenza's neuraminidase enzyme. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir prevents new viral particles from being released. Here you can see a classical crystal structure of influenza B neuraminidase in complex with Tamiflu (PDB code: 4CPM)
#molecularart ... #immolecular ... #oseltamivir ... #tamiflu ... #neuraminidase ... #influenza ... #inhibitor ... #xray
Structure of the neuraminidase complex rendered with @proteinimaging and depicted with @corelphotopaint
Oseltamivir is a neuraminidase inhibitor, a competitive inhibitor of influenza's neuraminidase enzyme. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir prevents new viral particles from being released. Here you can see a classical crystal structure of influenza B neuraminidase in complex with Tamiflu (PDB code: 4CPM)
#molecularart ... #immolecular ... #oseltamivir ... #tamiflu ... #neuraminidase ... #influenza ... #inhibitor ... #xray
Structure of the neuraminidase complex rendered with @proteinimaging and depicted with @corelphotopaint
